Radiotherapy of keloid (X-ray therapy)
Radiotherapy of keloid has very disputed effects. The method results in 50-100% relapse of keloids when applied as the only method. Superficial X-rays have been employed primarily as an adjunct to surgical removal of keloids. Radiotherapy of keloid should be started as early as possible (in the first 24 hours) after keloid excision. A total dose of usually 12 – 15 Gy is divided to 6-7 times (is recommended every second day). Side effects include hypo- and hyper-pigmentation, erythema, telangiectasia, post-radiation fibrosis and skin atrophy. Carcinogenicity is not proven, but the method is rarely used and only in combination with other methods. Radiotherapy of keloid is not used in children, in hair regions of the head, thyroid, face and breasts in women.
Pressure therapy for keloid and hypertrophic scars (Compression therapy)
Compression therapy or pressure therapy are effective for prevention of hypertrophic scars and treatment of keloids.
The continuous compression of 20-40 mm of mercury is applied for 12-24 hours per day in course of 3-12 months. On the one hand, it resists the scar tissue growth, holding it mechanically within limited space. On the other, by putting pressure on the scar vessels blocks its nutrition, specifically decreased oxygen supply to the scar tissue, which results in termination of its growth or partial regression. Pressure therapy is usually performed with pressure dressings or bandages, masks and gloves.
Silicone based products (silicone gel, silicone sheeting)
Mechanism of action of silicone sheeting for the treatment of hypertrophic scars and keloid is not been fully cleared. There are two points of view about it. The first opinion suggests that silicone sheeting normalize the transepidermal water loss and hydrate the scar. Another opinion suggests that silicone sheeting compress capillaries, block the delivery of inflammatory mediators, and reduce collagen synthesis due to local ischemia (Fig. 2). Silicone sheets are usually being employed 12–24 hours per day over a period of 6–12 months beginning 2 weeks after wounding.
Creams and gels for keloid and hypertrophic scars
Creams and gels for keloid and hypertrophic scars are applied depending on the stage and types of scars. They work in different ways: antibacterial, normalizing blood circulation, reducing collagen synthesis, smoothing the wound area, stimulating the immune protection of the wound area depending on ingredients. Creams and gels for keloid and hypertrophic scars that are recommended are the following: Kelo-cote, Dermatix, Strataderm, MedGel, Kelofibrase, Scarguard, Contractubex, Cicamed Scar. It goes without saying that one should consult a physician in any case in the selection of creams and gels. In the application of certain creams for scars they cannot be only ineffective, but can also worsen the appearance of the scar. As a rule, creams and gels for keloid and hypertrophic scars are used in parallel or after medical and device treatments during the maturation period of scars (Fig. 3).
It is impossible to remove keloids or hypertrophic scars with a cream or gel when a scar is already mature (1 year old)!
Laser treatment for keloids
Ablative lasers produce a high relapse rate (90-100%) when applied in hypertrophic scars and keloids treatment. Clinical efficacy with vascular laser (non-ablative) applied in hypertrophic scars treatment constitutes 75-95%, keloids – 60-70%. Primary task of laser treatment is to block in the keloid scar blood vessels that provide scar nutrition.
Intralesional corticosteroids for keloids
Corticosteroids are administered locally (to prevent keloid formation) by intralesional injections of triamcinolone acetonide injection (Kenalog crystalline suspension) to treat active keloids and old hypertrophic scars. Intralesional corticosteroid injections reduce collagen synthesis not only by inhibiting fibroblast mitosis (cells synthesizing collagen), but along with collagenase (collagen-resolving enzyme) concentration increase. Besides, steroids possess a strong anti-inflammatory action.
Cryosurgery or cryotherapy for keloids and hypertrophic scars
Mechanism of tissue damage by cryotherapy or cryosurgery using cryogen is conditioned by affection of microvasculature, destruction of cytoplasm and cell organelles caused by intracellular and intravascular formation of ice crystals. Concentration of electrolytes in cells is increased when thawing, accompanied by greater crystallization after repeated freezing which accelerates their destruction. When applied as a monomethod, cryotherapy results in complete elimination of keloids and hypertrophic scars with 51 and 74% relapse-free of cases, correspondingly.
The combination of cryotherapy or cryosurgery with other techniques much more efficient and provides positive results in 76-90% after 30 month follow-up period. (Dr. Igor Safonov: Cryotherapy of ear keloid).
Microneedling (dermapen, dermaroller) for keloids and hypertrophic scars
Microneedling for keloids and hypertrophic scars can be applied in any regions of human body. Collagen fibers in keloids are located differently compared to regular scars. They are located relatively in parallel to the skin surface in the normotrophic scars (Fig.6) and chaotically and node-like, resembling a fingerprint in keloids (Fig.7). Microneedles of dermapen or dermaroller penetrate into the skin up to the mesoderm and mechanically destroy the scar tissue fibres (Fig.8). In this case, depending on the thickness, prescription and location of the scar microneedling with the length of needles from 0.5 mm to 2.5 mm are used.